HAVCR1 and acute kidney injury: In a recent clinical study enrolling patients with Acute Kidney Injury (AKI) while taking SGLT2is, Darawshi et al. found that, in this specific patients population, the biomarkers of distal renal tubular injury such as serum and urine Neutrophil Gelatinase-Associated Lipocalin (NGAL) levels were higher than the levels found in patients without AKI, whereas biomarkers of proximal renal tubular injury namely serum and urine kidney injury molecule-1 (KIM-1) levels were not significantly different between the two groups (78).