In this regard, based on a recently described approach (Logotheti et al., 2020), we classified all cell lines of the Cancer Cell Line Encyclopedia (CCLE; Barretina et al., 2012), which includes gene expression data of 962 cell lines, into highly-invasive and less-invasive types, according to the levels of E-cadherin, N-cadherin, Vimentin, ZEB1, and SNAI1, which constitute reliable markers for EMT and tumor progression (Khan et al., 2017). This evidence concerns the gene ZEB1 and cancer.