DEFB1 also induces formation of neutrophil extracellular traps (NETs) (Álvarez et al., 2018), mesh-like structures composed of cytosolic and granule proteins which are assembled on a scaffold of decondensed chromatin fibers in a process termed NETosis, which has been proposed to protect tumor cells from T cell- or natural killer (NK) cell-mediated toxicity (Teijeira et al., 2020). This evidence concerns the gene DEFB1 and neoplasm.