IRAK1 and neoplasm: We also detected other epigenetically regulated genes in this signature, including CD70, IRAK, IL20RA, THBD, TACSTD2, and MST1R, with implications related to the tumor immune microenvironment (Jain et al., 2014; Rossi et al., 2014; Babicky et al., 2019; Gu et al., 2020; Kumar et al., 2020; Gao et al., 2021).