Using CRCs from colorectal cancer patients, Kim et al. (2018) found that ATP6V0C encoding lysosomal V-ATPase V0 subunit C and IDF-11774 (a new clinical drug candidate for the treatment of colorectal cancer) are synthetically lethal and that this effect was associated with the expression of B-cell CLL/lymphoma 2 (Bcl-2) and PIK3CA mutations. Here, BCL2 is linked to colorectal cancer.