Hence, we propose that a dual reporter including one of the pluripotency markers (phOCT4-EGFP/NANOG-GFP/SORE6-GFP/SOX2 SRR2-pGreen fire) and ALDH1A1-DsRed2 can efficiently mark all the heterogeneous CSCs, at least in breast cancer. This evidence concerns the gene SOX2 and breast cancer.