PROM1 and metastatic neoplasm: However, mutations of at least three genes among the seven genes (RNF144A, PAK2, PARP4, ADAM21, HYDIN, KRT38, and CELSR1) was consistently observed in CD133+ cells, while all the seven mutations were observed in metastatic tumor cells, suggesting that a subset of CD133+ cells are primarily responsible for establishing metastatic lesions (Min et al., 2020).