Although VGLL4 is rarely mutated in human cancer, it is located at the short arm (3p) of chromosome 3, which is lost in many types of cancer (Williamson, 2002; Cancer Genome Atlas Research Network, 2013; Jonasch et al., 2020; Nidorf et al., 2020; Shaikh et al., 2020). Here, VGLL4 is linked to cancer.