In recent years, some biomarkers resulting from methylation aberration have also shown their prognostic value in CRC, taking as an example the methylation of the following genes: TAC1, IGFBP3, CDKN2A (p16), SEPT9, HPP1, TFPA2E, EVL, HLTF, CD109, BNIP3, NRCAM, MLH1, MGMT, CDKN2A (p14), and APC (Ma et al., 2019). This evidence concerns the gene CDKN2A and colorectal carcinoma.