MGMT and glioblastoma: Zhang et al. (2019) proved that the expression of circFOXO3 was also significantly associated with wild-type IDH expression and MGMT methylation. They found that miR-138-5p and miR-432-5p jointly targeted nuclear factor of activated T cells 5 and restricted its expression, while circFOXO3 could remove this restriction and promote the proliferation and invasion of GBM cells (Zhang et al., 2019). At the same time, Chen et al. (2020) showed that plasma circFOXO3 was highly expressed in patients with GBM and had predictive significance for the occurrence of GBM.