MGMT and glioblastoma: What’s more, GBM can be divided into isocitrate dehydrogenase (IDH) wild type and IDH mutant type at the gene molecular level, and the efficacy of chemotherapy in GBM patients is closely related to the methylation state of O6-methylguanine-DNA methyltransferase (MGMT; Miller et al., 2017; Schaff et al., 2020).