BMDMs treated with 30% culture supernatant from PAAD cells with IFI16 overexpression exhibited a higher level of CD11b + F4/80 + population after 7-day incubation, suggesting that IFI16 overexpression in PAAD cells can increase the maturation of TAMs from monocytic cells in the tumor microenvironment (Figure 4A). This evidence concerns the gene ITGAM and neoplasm.