CD4 and neoplasm: Interestingly, IFI16 overexpression specifically increased the population of CD11b + F4/80 + macrophages in the tumor microenvironment but had minimal effect on the populations of CD11b + CD11c + dendritic cells, CD3 + CD4 + CD8- T helper cells, and CD3 + CD4-CD8 + cytotoxic T cells, suggesting that the effect of IFI16 overexpression in PAAD cells may specifically target TAMs in the tumor microenvironment (Figure 2D, gating shown in Supplementary Figure 1).