IFI16 and neoplasm: BMDMs treated with 30% culture supernatant from PAAD cells with IFI16 overexpression exhibited a higher level of CD11b + F4/80 + population after 7-day incubation, suggesting that IFI16 overexpression in PAAD cells can increase the maturation of TAMs from monocytic cells in the tumor microenvironment (Figure 4A).