We propose that the NONHSAT099004.2–miR-128-3p–ERG, MSTRG.85559.41–miR-150-5p–ITGB3 and MSTRG.34071.2–miR-146a-5p–FAXDC2 axes may play stimulative roles in the disease activity and severity of SLE. This evidence concerns the gene ITGB3 and systemic lupus erythematosus.