STAT3 and neoplasm: Interestingly, in preclinical tumor models, siRNA-regulated expression of STAT3, STAT6, IKKβ HIF-1α proteins for TAM differentiation (Shobaki et al., 2020; Xiao et al., 2020), and of CCR2 receptor for monocyte recruitment (Shen et al., 2018) enriched the TIME of antitumor M1-like macrophages and reduced the number of immunosuppressive cells.