Overall, the results show that when compared to a placebo, a 3-month clinical intervention of L-GSH supplementation in T2DM subjects resulted in significantly increased production of IFN-γ (Figures 6B, C) and TNF-α (Figures 6D, E) within granuloma supernatants in response to an in vitro BCG infection. This evidence concerns the gene TNF and type 2 diabetes mellitus.