For example, the Internal tandem duplication (ITD) mutations in Fms-like tyrosine kinase 3 gene (FLT3-ITD) are known to be associated with the upregulation of the glycolytic gate keeper enzyme hexokinase 2 (HK-2) and increased glycolytic activity in AML. The gene discussed is FLT3; the disease is acute myeloid leukemia.