TP53 and acute myeloid leukemia: We further confirmed that BDH1 expression level was negatively correlated with the expression levels of oncogenes, e.g., HOXA9 and MEIS1, but was positively correlated with the tumor suppressor TP53. The regulatory mechanisms of BDH1 on AML leukemogenesis and therapy, as well as on the expression of HOXA9, MEIS1 and TP53 are no doubt worth further investigation.