We then cultured preOCs with the CM from coculturing MSCs with myeloma cells in the presence of anti-EGFR neutralizing antibody, and we observed less TRAP+ cells when EGFR were inhibited (Figure 6F), indicating that myeloma cell-mediated osteoclastogenesis can be eased by deactivation of EGFR. The gene discussed is ACP5; the disease is plasma cell myeloma.