Our results show that myeloma cell integrin α6 binds to laminin 8 and epidermal growth factor receptor (EGFR) on MSCs, forms a trimer complex, activates the ERK1/2, STAT1/3, PI3K/Akt signaling pathways, enhances the secretion of osteolytic cytokines from myeloma cells and MSCs. The gene discussed is EGFR; the disease is plasma cell myeloma.