IL6 and plasma cell myeloma: Using qPCR analysis, we identified top four cytokines: inflammatory protein 1-alpha (MIP-1α), interleukin (IL)-6, -8, and -12, which were not only upregulated in MSCs cocultured with myeloma cells compared to MSCs alone, but was significantly downregulated in MSCs exposed to integrin α6 knocked down myeloma cells when compared with that in MSCs exposed to control myeloma cells (Figure 4A).