Supplementary Material C1 shows the survival analysis of CASD1, FAM86B1, KRBA2, and the other four genes results with P-values < 0.05 based on some non-differential genes in sJSD signal biomarker groups of BLCA. A higher level of ICI score in CASD1, FAM86B1, KRBA2, and 43892 is significantly related to a good prognosis, i.e., positive “dark genes”. While a higher level of ICI score in C15orf52, KRBA1, and UBBE2D4 is significantly related to poor prognosis, i.e., negative “dark genes” (Table 4). The gene discussed is KRABD2; the disease is bladder transitional cell carcinoma.