Besides, The GO analysis shows that high-frequency genes (Supplementary Table S1) of CESC are involved in the following biological processes (Figure 5D), axon Guidance (GO:0007411), enzyme Binding (GO:0019899), focal adhesion (GO:0005925), etc. The enrichment analysis of KEGG signaling pathways (Figure 5D) shows the high-frequency genes are primarily involved in Dilated cardiomyopathy (DCM), Hypertrophic cardiomyopathy (HCM), and cGmp-Pkg signaling pathway, etc. These biological processes and signaling pathways are closely related to the deterioration of CESC. The gene discussed is PRKG1; the disease is hypertrophic cardiomyopathy.