GNRH1 and cancer: The enrichment analysis of KEGG signaling pathways shows that the high-frequency genes are mainly involved in signaling pathways (Table 2) such as the GTPase activator activity, GnRH signaling pathway, pathways in cancer and inflammatory mediator regulation of TRP channels, etc. Figure 5B shows the significance level of each high-frequency gene in the sJSD signal biomarker groups which is enriched to the biological process.