Supplementary Material C1 shows the survival analysis of CASD1, FAM86B1, KRBA2, and the other four genes results with P-values < 0.05 based on some non-differential genes in sJSD signal biomarker groups of BLCA. A higher level of ICI score in CASD1, FAM86B1, KRBA2, and 43892 is significantly related to a good prognosis, i.e., positive “dark genes”. While a higher level of ICI score in C15orf52, KRBA1, and UBBE2D4 is significantly related to poor prognosis, i.e., negative “dark genes” (Table 4). Here, CASD1 is linked to bladder transitional cell carcinoma.