PFKFB3 and leukemia: Moreover, some of the ADM co-expressed genes are already known for their leukemia-related role, including the anti-apoptotic gene BIRC3, the signaling molecules HCK, LYN (tyrosine kinases), SLA (Src kinase-like-adapter protein) and PLAUR (urokinase plasminogen activator surface receptor), the transcriptional regulators TCF7L2 (WNT pathway) and ID2, the metabolism-related genes FTH1, FTL (ferritin heavy and light chain, respectively), PFKFB3 (glycolytic regulator), NAMPT (NAD biosynthesis pathway), SLC15A3 (solute carriers transporting histidine) and FFAR2 (free fatty acid receptor).