ADM and acute myeloid leukemia: The elevated ADM expression in AML was confirmed in our qRT-PCR analysis of CD34+ AML cells versus bone marrow hematopoietic stem-progenitor cells (HSPC, p = 0.017, Figure 2D) and in the GSE158596 dataset, by comparing leukemic blasts with G-CSF mobilized HSPC (p <0.001, Figure 2E).