Moreover, some of the ADM co-expressed genes are already known for their leukemia-related role, including the anti-apoptotic gene BIRC3, the signaling molecules HCK, LYN (tyrosine kinases), SLA (Src kinase-like-adapter protein) and PLAUR (urokinase plasminogen activator surface receptor), the transcriptional regulators TCF7L2 (WNT pathway) and ID2, the metabolism-related genes FTH1, FTL (ferritin heavy and light chain, respectively), PFKFB3 (glycolytic regulator), NAMPT (NAD biosynthesis pathway), SLC15A3 (solute carriers transporting histidine) and FFAR2 (free fatty acid receptor). Here, TCF7L2 is linked to leukemia.