Remarkably, network analysis of the ADM co-expressed genes across AML datasets highlighted the enrichment of transcripts involved in immune and inflammatory response, including myeloid leukocyte activation, regulation of their differentiation, neutrophil migration, toll-like receptor signaling, mononuclear cell migration, regulation of leukocyte proliferation (Figure 4 and Supplementary Table 4), suggesting an association between high ADM levels and an inflammatory status in leukemic cells. The gene discussed is ADM; the disease is acute myeloid leukemia.