To this aim, we analyzed six independent datasets of newly-diagnosed AML (excluding M3 cases, age ≥18 years) and focused on bone marrow samples (GSE6891, n = 68; Beat AML, n = 142; TCGA-LAML, n = 135, GSE13159, n = 458, NGS-PTL, n = 61), except for GSE14468 cohort that included mixed bone marrow and peripheral blood samples (n = 459, tissue not specified, Table 1 and Supplementary Table 2). Here, PNLIP is linked to acute myeloid leukemia.