In multivariate analysis, HPV negativity (HR, 12.367; 95% CI, 1.30-117.05; P= 0.028), PD-1high expression status (HR, 5.91; 95% CI, 1.03-33.82; P= 0.046) and low CD8+/CD4+ TIL ratio (HR, 22.498; 95% CI, 3.66-138.39; P= 0.001) correlated with early recurrence in cervical cancer (Table 2). The gene discussed is CD4; the disease is cervical carcinoma.