CD4 and cervical cancer: Therefore, in this study, we hypothesize that (1) either the intensity of PD-1 expression (PD-1high VS PD-1low) or the frequency of key ICRs (PD-1 and Tim-3) on CD8+ TILs may have a prognostic value as a cellular biomarker in cervical cancer patients; (2) CD8+ and CD4+ TIL ratio is linked to the outcome of cervical cancer.