In Ph-B-ALL, 17 cases harbored the IKZF1 and CDKN2A/B (I&C) deletions simultaneously, and these patients had worse OS and RFS than patients with no I&C deletion (N=64): 2-year OS: 34.3 ± 11.8% vs. 73.3 ± 5.5%, P=0.007; 2-year RFS: 33.3 ± 12.2% vs. 61.7 ± 6.3%, P=0.058 (Supplementary Figures S3A, B). The gene discussed is CDKN2A; the disease is acute lymphoblastic leukemia.