The multivariate analysis revealed that the N-CA125 HCC group had a significantly better OS and RFS rate than the H-CA125 HCC group [hazard ratio (HR) for OS = 1.441, 95% confidence interval (CI) = 1.194–1.739, p<0.001; HR for RFS = 1.292, 95% CI = 1.090–1.531, p = 0.003]. Here, MUC16 is linked to hepatocellular carcinoma.