In this study, we used the transcriptome profiling and the corresponding clinical information of HCC patients, obtained from the TCGA database, to identify a six metabolism-related gene signature (G6PD, AKR1B15, HMMR, CSPG5, ELOVL3, FABP6) for the prognostic evaluation of HCC, and verified them in the ICGC database. The gene discussed is G6PD; the disease is hepatocellular carcinoma.