In this study, we used the transcriptome profiling and the corresponding clinical information of HCC patients, obtained from the TCGA database, to identify a six metabolism-related gene signature (G6PD, AKR1B15, HMMR, CSPG5, ELOVL3, FABP6) for the prognostic evaluation of HCC, and verified them in the ICGC database. This evidence concerns the gene CSPG5 and hepatocellular carcinoma.