In summary, the published works suggested that these candidate genes and corresponding proteins were involved in the tumor progression across various cancer types, which were consistent to our risk signature, where ALDH1L2, ANXA1, CERCAM, GNA12, and PLOD1 were risk factors, whereas GSDMB served as a protective factor for bladder cancer. The gene discussed is ANXA1; the disease is urinary bladder carcinoma.