Not only the activation and inhibition of mitochondrial biogenesis, but also the mitochondrial overload and dysfunction have been described to drive invasiveness of cancer cells (89, 111, 114), since it may activate the protein tyrosine kinases Src and Pyk2, known to drive cancer cells motility by remodeling cell-cell and cell-matrix interactions (89). The gene discussed is PTK2B; the disease is cancer.