The function of Tagln2 has not yet been clarified, but recent reports have demonstrated that certain tumors, including those of colorectal cancer (3), bladder cancer (4), uterine cervical squamous cell carcinoma (5), esophageal squamous cell carcinoma (6) and gliomas (7), exhibit Tagln2 overexpression. Here, TAGLN2 is linked to esophageal squamous cell carcinoma.