ALCAM and cancer: Adhesion molecule including CEACAM-1, NrCAM (implicated in pro-angiogenic signaling, and enhance of vasculature permeability), ALCAM (acted in invasion and metastasis of several primary tumors), and ICAM-3 (identified on vessels in malignant tumors, correlated with the level of vascular differentiation) (17–19) were upregulated.