The IL-1RN rs419598 wild-type genotype was significantly related to stage III-IV disease, the PIGR rs291102 wild-type genotype was significantly related to normal levels of cytokeratin fragment 19 (CYFRA), and the BCL2 rs2279115 wild-type genotype was significantly related to lymph node metastasis. This evidence concerns the gene PIGR and metastatic malignant neoplasm in the lymph nodes.