Some scholars consider that TNF-α SNPs (rs1800629, rs1799724, rs1800630, and rs1799964) may individually or, more likely, jointly affect individual susceptibility to HPV16-associated OSCC, particularly squamous cell carcinoma of the oropharynx (SCCOP) in never smokers (38). The gene discussed is TNF; the disease is oropharynx squamous cell carcinoma.