In addition, in men, the AKT1 rs1130233 TT genotype and dominance model (CT+TT vs. CC) and the BCL2 rs2279115 TT genotype and recessive model (TT vs. GT+GG) conferred a 0.37-fold, 0.43-fold, 0.37-fold, and 0.41-fold reduction in HNSCC progression, respectively. The gene discussed is AKT1; the disease is head and neck squamous cell carcinoma.