However, in those age 60 and younger, the AKT1 rs1130233 TT genotype and dominance model (CT+TT vs. CC), the IL-21R rs2189521 CT genotype and dominance model (CT+ CC vs. TT), and the BCL2 rs2279115 recessive model (TT vs. GT+GG) were associated with reduced HNSCC risk. The gene discussed is IL21R; the disease is head and neck squamous cell carcinoma.