However, in those age 60 or younger, the AKT1 rs1130233 TT genotype and dominance model (CT+TT vs. CC), IL-21R rs2189521 CT genotype and dominance model (CT+ CC vs. TT), and BCL2 rs2279115 recessive model (TT vs. GT+GG) conferred a 0.48-fold, 0.57-fold, 0.61-fold, 0.60-fold, and 0.49-fold reduction in HNSCC progression, respectively. This evidence concerns the gene IL21R and head and neck squamous cell carcinoma.