Furthermore, based on our previous study that FHL3 regulated the Akt/GSK3β/ubiquitin-Snail1|Twist1 pathway to stabilize the EMT-TFs to promote EMT process in pancreatic cancer, we explored the role of FHL3 in the regulation of ubiquitin-mediated EMT. The gene discussed is TWIST1; the disease is familial pancreatic carcinoma.