The multivariate Cox proportional hazards model showed lymph node metastasis (Hazard ratio = 1.47, 95% CI: 1.09–1.98, P = .011, Table 2) and FHL3 (Hazard ratio = 2.06, 95% CI: 1.23–3.42, P = 0.005, Table 2) were the independent risk factors of overall survival in GC. The gene discussed is FHL3; the disease is gastric cancer.