As we expected, when NSCLC cells were treated with lactate, histone lactylation level increased (Figure 7A), along with down-regulated transcription of HK-1 (Figure 7B), G6PD (Figure 7C) and PKM (Figure 7D) as well as up-regulated transcription of SDH (Figure 7E) IDH and HIF1A (Figure 7F). Here, PKM is linked to non-small cell lung carcinoma.