Alterations of two genes, TP53 (9/14 vs. 4/18, p = 0.029) and GBF1 (4/14 vs. 0/18, p = 0.028), were found to be significantly enriched in lymph node-positive samples (Figure 3B), suggesting the occurrence of such genomic events during tumor progression may potentially promote regional lymph node metastasis. The gene discussed is TP53; the disease is neoplasm.