TTN and penile carcinoma: TP53 (13, 40.63%), NOTCH1 (12, 37.50%), CDKN2A (11, 34.38%), TTN (9, 28.13%) and FAT1 (8, 25.00%) were found to be the most common repeatedly mutated genes in this cohort (Figure 1B), which have been reported to be frequently mutated in penile carcinoma.