FZD8 and cancer: It is noteworthy that “Pathways in cancer” was the most enriched pathway in which Ras-related C3 botulinum toxin substrate 2 (RAC2), guanine nucleotide-binding protein subunit beta-4 (GNB4), prostaglandin E2 receptor EP4 subtype (PTGER4), G1/S-specific cyclin-E2 (CCNE2), Frizzled-8 (FZD8), transforming growth factor beta-3 (TGFB3), laminin subunit alpha-2 (LAMA2), glutathione S-transferase Mu 1 (GSTM1), and matrix metalloproteinase-2 (MMP2) are involved.