157 septic patients were enrolled in this retrospective study. Biomarkers such as procalcitonin, presepsin, galectin-3, and soluble suppression of tumorigenicity 2 were evaluated and their concentrations were analyzed in relation to the 30-day all-cause mortality. Results showed a possible prognostic utility of all four biomarkers in sepsis. This multi-biomarker approach could be a beneficial approach for an optimized management of sepsis patients. The gene discussed is LGALS3; the disease is Sepsis.