207 patients were enrolled in a multi-center prospective study which aimed to assess the clinical usefulness of presepsin in bacterial and non-bacterial infections. Levels of presepsin, PCT, and IL-6 were significantly higher in patients with bacterial infectious disease. Presepsin levels did not differ significantly between patients with gram+ and gram- bacterial infections. The usefulness of presepsin for diagnosing sepsis was concluded, also presepsin possible superiority to conventional biomarkers and blood culture. The gene discussed is IL6; the disease is Sepsis.