The diagnostic accuracy of presepsin in predicting bacteraemia and bacterial DNAaemia in patients with suspected sepsis, and its comparison with that of PCT and CRP was assessed in this study. The presepsin median values were significantly higher in bacteraemic vs non-bacteraemic patients and in patients with bacterial DNAaemia vs patients without. This study concluded that when sepsis is suspected, presepsin and PCT had a good diagnostic accuracy in predicting both bacteraemia and bacterial DNAaemia, superior to CRP. Here, CRP is linked to Sepsis.