58 ICU patients with suspected sepsis were enrolled in an observational, prospective study which aimed to evaluate the role of presepsin in predicting the outcome in parallel with procalcitonin and CRP. Presepsin levels were significantly higher in non-survivors vs survivors at the same time point. Presepsin concentrations were also significantly increased in patients with positive blood cultures. The authors concluded that presepsin has an optimal prognostic and diagnostic value in patients with severe sepsis. This evidence concerns the gene CRP and Sepsis.