Plasma presepsin, PCT and CRP levels in patients with SIRS and suspected sepsis were serially measured in order to evaluate the diagnostic and prognostic performance of presepsin in comparison to PCT and CRP. Results of the study showed that presepsin and PCT yielded similar diagnostic accuracy, whereas presepsin performed significantly better than CRP. Presepsin and PCT had comparable accuracy in differentiating between septic and non-septic patients. Finally, early changes in presepsin concentrations might reflect the appropriateness of the therapeutic modality. Here, CRP is linked to systemic inflammatory response syndrome.