CRP and Sepsis: The diagnostic accuracy of presepsin for infection and sepsis, compared with PCT and CRP was evaluated in the emergency department (ED) setting. 223 patients with suspected infection were enrolled in the study. Results showed that median CRP, PCT and presepsin levels were significantly higher in patients with infection and sepsis. PCT had the highest performance for infection and for sepsis, PCT and presepsin performed a similar one. The diagnostic accuracy of presepsin in this study does not improve that of PCT.