This prospective study investigated the plasma levels of presepsin in fungal bloodstream infections in relation to the disease severity and in comparison to bacterial infections. The investigators assessed the associations of CRP, procalcitonin, and presepsin concentrations with the severity of fungemia. Plasma presepsin levels were found elevated in patients with fungal bloodstream infection, with a positive relation to the disease severity. They concluded that presepsin could be a useful biomarker of sepsis due to fungal infections. Here, CRP is linked to fungal infectious disease.