Procalcitonin, C-reactive protein, presepsin and lactate were analyzed in 60 consecutive patients with sepsis and SIRS in the study. The SOFA score was determined also daily in patients’ assessment. The results of the study showed that presepsin did not outperform the traditional biomarkers in diagnosing sepsis from SIRS and in mortality prognosis in critically ill patients. The authors concluded that presepsin may have a limited adjunct value for diagnosis and early risk stratification, performing independently of clinical illness severity. This evidence concerns the gene CRP and Sepsis.