Thus, Mann-Whitney U test was performed and identified that the levels of monocyte (p<0.001), MCV (p=0.018), MCH (p=0.01), MPV (p=0.022), PT (p=0.003), PT-INR (p=0.003), PDW (p<0.001) and MLR (p<0.001) in the early esophageal cancer patients were significantly higher than those in the control group, while the levels of lymphocyte (p<0.001) and RBC (p=0.003) were significantly lower in the early esophageal cancer patients. The gene discussed is PMCH; the disease is esophageal cancer.