In turn, high GFRAL expression was marginally significantly associated with shorter survival time (507 days) of GC patients in comparison to those with its low expression level (1043 days, P = 0.05; Figure 3C), with HR calculation indicating an increase in relative risk of death from any cause of 1.81 (95% CI 0.98-3.35, P = 0.06). The gene discussed is GFRAL; the disease is gastric cancer.