Importantly, based on our preclinical finding, docetaxel trihydrate, pelitinib, and uprosertib have significant anti-cancer effects in cancers with low RNF43 and PWWP2B expression (HAP1 RNF43 KO, HAP1 PWWP2B KO cells, MKN45 cells, and KMN45 xenografts). The gene discussed is PWWP2B; the disease is cancer.