Importantly, based on our preclinical finding, docetaxel trihydrate, pelitinib, and uprosertib have significant anti-cancer effects in cancers with low RNF43 and PWWP2B expression (HAP1 RNF43 KO, HAP1 PWWP2B KO cells, MKN45 cells, and KMN45 xenografts). This evidence concerns the gene RNF43 and cancer.