CREBBP and neoplasm: To investigate the effect of CREBBP knockdown on tumorigenesis in vivo, a cell line-derived xenograft tumor model was established by subcutaneously injecting CREBBP knockdown and the corresponding control cells (HEY shCBP-1, HEY shCBP-2, and HEY shLuc) into the bilateral flanks of BALB/c nude mice.