AKT1 and hepatocellular carcinoma: In addition, we examined the migration and invasion capability of Bel-7402 cells, and observed that PI3K/AKT inactivation abolished the cell migration and invasion promoted by dnMST4 expression (Figure 4B and 4C), suggesting the necessary role of PI3K/AKT inactivation in MST4 inhibiting the invasive and metastatic potential of HCC cells.