Low testosterone levels, but again not increased LH levels, are also associated with macrovascular disease—decreased levels in patients with ischemic heart disease, cerebrovascular disease, and peripheral vascular disease—but differences never reach statistical significance, not even when considering the composite MACRO index; this may depend at least in part on the low rate of these complications and the crude nature of clinical evaluation. The gene discussed is PLOD1; the disease is cerebrovascular disorder.