BK channels: voltage-dependent large-conductance Ca2+-activated K+ channels; Kv channel: voltage-gated K+ channel; LQT: long QT syndrome; Rseal: seal resistance; Rs: series resistance; If: fractional current remaining; Imax: the maximum value of the current amplitude; V1/2: the half-maximal voltage; Po: the open probability. The gene discussed is KCND3; the disease is Prolonged QT interval.