As a result, SHMT2 expression was significantly upregulated both in BLCA-Genechip (10 normal bladder samples versus 144 BLCA samples, P = 7.58E-07) and RNA-seq (30 normal bladder samples versus 411 BLCA samples, P = 1.68E-04) compared to that in the normal tissues (Figure 2D). Here, SHMT2 is linked to bladder transitional cell carcinoma.