It was indicated that BLCA patients with a high SHMT2 mRNA expression were correlated with a poorer overall survival (OS) [Hazard Ratio (HR) = 1.4, P(HR) = 0.027] than patients with a low SHMT2 mRNA expression (Figure 3A); however, a high SHMT2 expression was not related to disease-free survival (DFS) (HR = 1.2, P(HR) = 0.32 (Figure 3B). This evidence concerns the gene SHMT2 and bladder transitional cell carcinoma.