Similar to the findings obtained using GEPIA, a high SHMT2 expression was significantly associated with a poorer OS of BLCA patients [GSE13507 (Kim et al., 2010), total number = 165, HR = 1.39, P = 0.042], but was not correlated with the DFS (total number = 165, HR = 1.57, P = 0.067) of BLCA patients (Figures 3C,D). This evidence concerns the gene SHMT2 and bladder transitional cell carcinoma.