Biallelic mutations of FKBP10 cause osteogenesis imperfecta (MIM 610968; Alanay et al., 2010) or Bruck syndrome (MIM 259450; Shaheen et al., 2010), two allelic conditions with bone fragility and skeletal impairments. This evidence concerns the gene FKBP10 and osteogenesis imperfecta.