PRSS53 and ductal breast carcinoma in situ: Out of the 10 genes, six are related to the tumor microenvironment (COL10A1, COL1A1, MFAP2, PRSS33, PRSS53, and MMP11), and these genes showed predictive power for recurrent DCIS (Figure 7), although its added value for clinical practice remains to be investigated on a larger series.