Out of the 10 genes, six are related to the tumor microenvironment (COL10A1, COL1A1, MFAP2, PRSS33, PRSS53, and MMP11), and these genes showed predictive power for recurrent DCIS (Figure 7), although its added value for clinical practice remains to be investigated on a larger series. This evidence concerns the gene COL1A1 and neoplasm.