PPIP5 kinases (e.g., PPIP5K2) mediate PP-IP binding, activate casein kinase 2 (CK2), and promote the phosphorylation of the TTT complex, which stimulates DNA-PK/ATM to activate p53 on the cancer cells (Fridy et al., 2007; Lee et al., 2020). Here, TP53 is linked to cancer.