For the “Pathway in cancer” pathway (Figure 4D), a total of 18 risk lncRNAs synergistically regulated ER (ESR1), E2F (E2F1 and E2F2), CyclinA1 (CCND1), and Survivin (BIRC5), which indirectly leads to tumor cell proliferation. This evidence concerns the gene ESR1 and neoplasm.