IGFBP6 and cancer: The association between IGFBP6 and cancer appears to be more obvious, as a large number of studies on the role of the IGF/IGF1R signaling pathway in oncogenesis have been carried out to date (Trajkovic-Arsic et al., 2013; Brouwer-Visser and Huang, 2015; Salisbury and Tomblin, 2015; Vigneri et al., 2015; Tracz et al., 2016).