ELOVL5 and cancer: However, this is not an entirely unexpected result, as previously, it was shown that omega-3 and omega-6 PUFAs, the products of ELOVL5 activity, affect the proliferation, migration, and invasion of cancer cells in vitro (Chamras et al., 2002; Yun et al., 2014; Gonzalez-Reyes et al., 2017; Huang et al., 2017) and that dietary omega-3 FAs reduce the risk of BC development, as well as the risk of its relapse (Abdelmagid et al., 2016; Playdon et al., 2017; Romieu et al., 2017; Shapira, 2017).