However, on the basis of the analysis of large microarray dataset of BC samples (kmplot.com), it can be concluded (Supplementary Figure 1) that high expression of each ELOVL5 [hazard ratio (HR) = 0.54, p < 0.001] and IGFBP6 (HR = 0.76, p < 0.001) messenger RNAs (mRNAs) is associated with better distant metastasis-free survival (DMFS) (Györffy et al., 2010). This evidence concerns the gene IGFBP6 and breast cancer.