In contrast, the 1,490 genes specifically regulated in silicosis were mainly involved in antigen presentation by MHC class I molecules, CD8 + Tcl cells, mucociliary clearance function, epithelial progenitor cells differentiation, and OX40L/OX40 signaling (Figure 3B and Supplementary Table 13). Here, TNFSF4 is linked to silicosis.