Specifically, some relevant genes revealed by previous research did not show significant alterations in our results, such as the genes Ccl2 and Ccr2, which have been validated in mice silicosis models (Chen J. et al., 2018), and the DNA-binding protein inhibitor (ID) family genes, which were found to be relevant in the early responses of silicosis in epithelial cells (Chan et al., 2017). The gene discussed is CCL2; the disease is silicosis.