PRKN and Parkinson disease: However, extensive literature studies reviewed the contribution of PD causative genes (a-syn, Parkin and DJ-1) in innate immune responses, the immunoregulatory role of dopamine and the disruption of Blood-Brain-Barrier integrity in PD (Bossù et al., 2015; Troncoso-Escudero et al., 2018; Garretti et al., 2019; Matt and Gaskill, 2020).