We found that the mRNA levels of OASL (median: 126.35, IQR 61.87–308.20 vs. 208.50, IQR 158.70–479.22, p = 0.039), MX1 (median: 450.10, IQR 251.20–1296.00 vs. 980.20, IQR 335.70–2797.50, p = 0.007), and LY6E (median: 178.40, IQR 78.40–332.65 vs. 273.60, IQR 145.30–576.70, p = 0.050) in active SLE patients were significantly higher than those in patients with inactive SLE. The gene discussed is LY6E; the disease is systemic lupus erythematosus.