Among SLE patients, mRNA levels of OAS1 (median 171.65, IQR 103.52–364.12 vs. 269.80, IQR 90.20–1063.60, p = 0.985) and ISG15 (median 0.15, IQR 0.07–0.46 vs. 0.27, IQR 0.14–0.53, p = 0.355) were slightly higher in those who had active disease than in those who did not; however, the differences were not statistically significant. The gene discussed is ISG15; the disease is systemic lupus erythematosus.