Beyond that, to date, several WS cases associated with mutations in ENDRB, EDN3, and SNAI2 had been reported (Sánchez-Martín et al., 2002; Pingault et al., 2010; Xiong et al., 2015; Somashekar et al., 2019), but the situation is a bit different in Chinese. This evidence concerns the gene EDN3 and Werner syndrome.