ESR1 and breast carcinoma: Furthermore, to better understand the relevance and potential mechanisms of TACC3 expression in breast cancer, we investigated the relationship between the TACC3 expression and clinical characteristics of breast cancer patients and found that TACC3 expression was significantly associated with the ER, PR, HER2 status, nodal status, SBR, NPI, age, subtypes, and triple-negative and basal-like status.