METTL3 and neoplasm: Specifically, YTHDF1, IGF2BP2, KIAA1429, RBM15, IGF2BP1, ZC3H13, and METTL3 were significantly up-regulated in tumor tissues by unpaired T-tests (P < 0.05), while ALKBH5, YTHDC2, and METTL14 were significantly down-regulated (P < 0.01) (Figure 1B).