To evaluate if the decreased levels of hsa-miR-145-5p observed in SS-patients are associated with type I IFNs and the activation of this specific pathway, we assessed the effect of IFN-α or IFN-β stimulation on hsa-miR-145-5p levels and its targets MUC1 and TLR4 in HSG cells. The gene discussed is MUC1; the disease is synovial sarcoma.