In the present study, increased MUC1 mRNA induced by IFN-α and IFN-β together with functional assays using mimic hsa-miR-145-5p and inhibitors suggest that the type I IFN signaling increases MUC1 synthesis mediated by hsa-miR-145-5p inhibition in LSG of SS-patients. Here, IFNA1 is linked to synovial sarcoma.