Additionally, hsa-miR-145-5p overexpression alleviated lung tissue injury, decreased the expression levels of IL-1β, IL-6, and TNF-α and reduced myeloperoxidase activity in acute lung injury mouse model, demonstrating that miR-145-5p participated in the progression and development of acute lung injury by decreasing the production of pro-inflammatory cytokines (77). This evidence concerns the gene TNF and acute lung injury.