NK cells recognize specific ligands expressed on tumor cells that promote the engagement of an array of activating receptors such as DNAM-1, NKG2D, 2B4, NKG2C, the Natural Cytotoxicity Receptors (NCR) NKp30, NKp44, NKp46 and NKp80, and others (5). This evidence concerns the gene CD244 and neoplasm.